O-051 Refreezing and rebiopsy – are these worth it?
نویسندگان
چکیده
Abstract Preimplantation genetic testing of embryos offers the opportunity to avoid transmission hereditary disorders offspring by selecting out affected a single gene mutation or mutations (PGT-M), structural rearrangements chromosomes (PGT-SR), aneuploidy (PGT-A) as well polygenic risk (PGT-P). Over last two decades, laboratory techniques have seen tremendous developments including extended embryo culture blastocyst stage, trophectoderm biopsy and vitrification. The latter technique is highly efficient allows multiple freezing warming cycles when performed in proficient laboratories. At same time whole genome analysis provide analyse embryonic DNA great detail for indications simultaneously. PGT process sensitive both biological technical issues which sometimes lead failed result. Failure diagnosis reported occur between 2-12% depending on methodology used. main causes inconclusive are amplification failure non-concurrent results. Independent variables that influence results day biopsy, number cells taken at quality IVF laboratory. In order seize every reaching optimize reproductive outcome patient, rebiopsy retesting (double double cryopreservation) can be performed. situations where need biopsied reasons newly found clinical PGT-A, after an initial cryopreservation, cryopreservation may with potential effect subsequent outcome. A limited studies addressed feasibility success rate refreezing. Most conclude terms diagnostic efficiency outcome, expert few health children not shown increased risks. Larger needed establish true health-economic value speaker will give overview existing evidence literature assess whether it safe worthwile go extra mile consider refreezing PGT. Trial registration XXXX
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2023
ISSN: ['1460-2350', '0268-1161']
DOI: https://doi.org/10.1093/humrep/dead093.061